Fig. 3. Functional differences between the resolved and persistent pain groups.

Functional differences assessed with selected pathways in Gene Ontology’s (GO) biological processes. Statistically significant pathways at the FDR 10% level are highlighted in nongray colors; blue at t₀ (column I), orange for group P (column III), and green for group R (column IV). Assessment performed between the groups with resolved (R) and persistent (P) pain, at the first visit (column I), and at the second visit (column II). Functional trajectories between t₀ and t₁ are also shown for the P group (column III) and for the R group (column IV). (A) Pathways under inflammatory response (GO:0006954). (B) Pathways under leukocyte activation (GO:0045321). (C) Pathways under leukocyte degranulation (GO:0043299).