Figure 10. Conformation of the Switch II in the LRRK2^RCKW.

Left panel shows the α3^ROC helix and Switch II (red circle) with key residues highlighted. Right panel shows how this Switch II adopts a different conformation in LRRK2^RCKW compared with fl-LRRK2^INACT (Figure 7). The hydrophobic knob residues H1405 and F1401 in Switch II have rearranged significantly in LRRK2^RCKW. They now point towards CORA and the region from residues 1406–1411 is disordered. Additionally, R1398 is recruited to the ROC:CORB interface.