Figure 5. α3^ROC Helix in the fl-LRRK2.

The left panel shows the α3^ROC Helix of fl-LRRK2^INACT with highlighted key interactions, such as R1441 at the C-terminal end interacting with W1791 on the C-terminal end of the Dk-helix, R1398 pointing down interacting with T1368, and K1347 interacting with the GDP phosphate group. In this inactive conformation, residue Y1699 in the COR-B domain is pointing towards the N-terminus of the α3^ROC Helix. The right panel highlights key residues in the switch II region of the ROC domain (red circle). The sequence of the α3^ROC Helix is shown at the bottom, with PD mutation sites highlighted in red.