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Suggested algorithm for selecting a biologic agent for pediatric severe asthma. Note: Agents ordered alphabetically within each group. EOS, serum eosinophils; FeNO, fractional exhaled nitric oxide. 1Omalizumab only for allergic asthma (all other agents can be considered for both allergic and nonallergic asthma). 2Dupilumab only if EOS less than 1500 cells/μl.
