KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Normal donor human bone marrow samples	University of Texas Lymphoma/Myeloma Department Myeloma Tissue Bank	https://www.mdanderson.org/research/departments-labs-institutes/departments-divisions/lymphoma-myeloma.html
Myeloma precursor disease and multiple myeloma patient bone marrow samples	University of Texas Lymphoma/Myeloma Department Myeloma Tissue Bank	https://www.mdanderson.org/research/departments-labs-institutes/departments-divisions/lymphoma-myeloma.html
Critical commercial assays
Chromium Next GEM Single Cell 5’ Library and Gel Bead kit v1.1, 16 rxns.	10x Genomics	1000165
Chromium Single Cell V(D)J Enrichment Reagent Kits Human Bcells	10x Genomics	1000016
Chromium Next GEM Chip G Single Cell kit	10X Genomics	1000120
Qubit HS dsDNA Assay	ThermoFisher	Q32854
HS DNA Bioanalyzer	Agilent	5067–4626
KAPA Biosystems KAPA Library Quantification Kit	KAPA/Roche Diagnostics	KK4835/079602040 01
EasySep CD138 Positive Selection Kit	StemCell Technology	Cat#: 17887A
40-micron sterile cell strainer	VWR	Cat#: 21008–949
Density gradient centrifugation, LymphoPrep	StemCell Technology LymphoPrep	Cat#: 07851
Deposited data
Aligned scRNA-seq and scBCR-seq data of myeloma and precursors	This paper	EGAS00001006694
Bulk mRNA-seq expression data	NCI Cancer Genomic Data Commons	MMRF-COMMPASS
Software and algorithms
Cell Ranger-5.0.0	10x Genomics	https://www.10xgenomics.com/
R-4.0.0	R Core Team	https://www.r-project.org/
Seurat-4.0.3	Stuart et al.50	https://satijalab.org/seurat/
Harmony-0.1.0	Korsunsky et al.51	https://portals.broadinstitute.org/harmony
inferCNV-1.5.0	Tickle et al.53	https://github.com/broadinstitute/inferCNV
CytoTRACE	Gunsagar et al.40	https://cytotrace.stanford.edu/
Monocle2	Trapnell et al. (2014)41 Qiu et al. (2017)42,43	http://cole-trapnell-lab.github.io/monocle-release/
Monocle3–0.2.0	Trapnell et al. (2014)41 Qiu et al. (2017)42,43	http://cole-trapnell-lab.github.io/monocle-release/