Figure 3.

Interaction between methylenetetrahydrofolate dehydrogenase (MTHFD1_rs12236225) and methotrexate (MTX) dose (low or medium vs high) predicting verbal fluency. Means and 95% confidence limits are shown to illustrate that poor performance on the task was exacerbated among survivors who expressed the minor alleles and had been exposed to higher doses of methotrexate. DKEFS = Delis-Kaplan Executive Function System; Hetero = heterozygous allele; Major = major homozygous allele; Minor = minor homozygous allele.