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. 2023 Jun 7;7(4):pkad039. doi: 10.1093/jncics/pkad039

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Genetic mediators of functional magnetic resonance imaging (fMRI) activity among childhood acute lymphoblastic leukemia survivors. Group-level fMRI contrasts during the N-Back and attention network tasks based on genetic variants. Individuals with heterozygous and minor homozygous alleles (HeteroMinor) were compared with major homozygous alleles (Major) using multivariable analyses adjusted for age at evaluation and sex. Differences in brain activity were statistically significant for family wise error–corrected P values less than .05. Blood oxygen level–dependent (BOLD) activation differences were observed in A) the left angular gyrus; B) right supramarginal gyrus; C) right orbital inferior frontal gyrus and supramarginal gyrus; and D) left caudate nucleus, basal ganglia, and inferior frontal gyrus.