Table 6. Univariable Cox regression overall, disease-free, and local recurrence-free survival analyses of treatment approach.
| OS—Univariable | DFS—Univariable | LRFS | ||||
|---|---|---|---|---|---|---|
| n | HR (95% CI) p -value |
n | HR (95% CI) p -value |
n | HR (95% CI) p -value |
|
| Endoscopic versus other surgical approach | 337 | HR = 0.76 (95% CI: 0.58–0.99) p = 0.039 |
217 | HR = 0.81 (95% CI: 0.59–1.10) p = 0.176 |
92 | HR = 0.81 (95% CI: 0.44–1.49) p = 0.495 |
| Surgery and Adj. RT versus surgery alone | 363 | HR = 0.74 (95% CI: 0.57–0.96) p = 0.021 |
254 | HR = 0.83 (95% CI: 0.63–1.10) p = 0.202 |
124 | HR = 0.62 (95% CI: 0.37–1.04) p = 0.066 |
| Surgery and Adj. CRT versus surgery and Adj. RT | 204 | HR = 1.65 (95% CI: 0.92–2.97) p = 0.114 |
147 | HR = 1.49 (95% CI: 0.79–2.78) p = 0.239 |
65 | HR = 1.15 (95% CI: 0.27–4.93) p = 0.852 |
Abbreviations: Adj. adjuvant; CI, confidence interval; CRT, chemoradiotherapy; DFS, disease-free survival; HR, hazard ratio; LRFS, local recurrence-free survival; OS, overall survival; RT, radiotherapy.