Table 1. Patient history, demographics, and imaging characteristics in early, middle, and late cohorts.
| Epoch | Total N = 66 |
2005–2010 ( N = 20) | 2011–2015 ( N = 23) |
2016–2020 ( N = 23) | Significance | |
|---|---|---|---|---|---|---|
| Age (median, interquartile range) | 39 (IQR 30.5–56.3) | 46.5 (30–56.8) | 39 (28–64.2) | 39 (32–67) | 0.435 | |
| Sex | Female | 25 (37.9%) | 8 (40%) | 10 (43.5%) | 7 (30.4%) | 0.642 |
| Presenting symptom | Vision loss | 60 (91%) | 20 (100%) | 23 (100%) | 17 (73.9%) | 0.002 |
| Headache | 31 (47%) | 8 (40%) | 13 (56.5%) | 10 (43.5%) | 0.510 | |
| Endocrinopathy | 18 (27%) | 4 (20%) | 9 (39.1%) | 5 (21.7%) | 0.284 | |
| Weight gain | 7 (11%) | 0 (0%) | 3 (13%) | 4 (17.4%) | 0.163 | |
| Fatigue | 10 (15%) | 1 (5%) | 5 (21.7%) | 4 (17.4%) | 0.291 | |
| Memory/cognitive | 6 (9%) | 2 (10%) | 0 (0) | 4 (17.4%) | 0.120 | |
| Prior surgery | Transcranial | 9 (14%) | 5 (25%) | 3 (13%) | 1 (4.3%) | 0.243 |
| Transsphenoidal | 5 (7.6%) | 2 (10%) | 2 (8.7%) | 1 (4.3%) | 0.345 | |
| Prior radiotherapy | 4 (6.0%) | 3 (15%) | 1 (4.3%) | 0 (0) | 0.139 | |
| Prior intracystic therapy | Ommaya reservoir | 1 (1.5%) | 0 (0) | 1 (1.5%) | 0 (0) | |
| Intracystic therapy | 0 (0) | 0 (0) | 0 (0) | |||
| Max tumor diameter, cm (median, interquartile range) | 2.91 (2.1–3.5) | 2.9 (2.3–4.2) | 3.0 (2.1–3.3) | 2.7 (2.1–3.2) | 0.415 | |
| Tumor consistency a | Solid | 6 (9.0%) | 3 (15%) | 2 (8.7%) | 1 (4.3%) | 0.785 |
| Cystic | 13 (20%) | 4 (20%) | 5 (21.7%) | 4 (17.4%) | ||
| Solid and cystic | 47 (71%) | 13 (65%) | 16 (69.6%) | 18 (82.6%) | ||
| Hypothalamic involvement b | 55 (83.3%) | 19 (95%) | 19 (82.6%) | 17 (73.9%) | 0.179 | |
| Pathology | Adamantinomatous | 47 (71.2%) | 14 (70%) | 15 (65.2%) | 18 (78.3%) | 0.501 |
| Papillary | 17 (25.8%) | 5 (25%) | 8 (34.8%) | 5 (21.7%) |
a
Tumor was graded as primarily cystic or solid if >90% of the tumor was cystic or solid, respectively.
b
Hypothalamic involvement was present if the tumor displaced or invaded the medial or inferior hypothalamus on at least one side. Bold values indicate significant level less than 0.05.