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. 2023 May 16;14(19):1812–1823. doi: 10.1111/1759-7714.14926

FIGURE 4.

FIGURE 4

CircERBB2IP negatively regulated miR‐5195‐3p by acting as a miR‐5195‐3p sponge. (a) The predicted core binding sequence of miR‐5195‐3p in circERBB2IP sequence. (b) Relative levels of miR‐5195‐3p in NSCLC cell lines with miR‐NC or miR‐5195‐3p. (c–g) The targeting relationship between circERBB2IP and miR‐5195‐3p was validated by luciferase assay (c and d), anti‐Ago2 radioimmunoprecipitation (RIP) assay (e and f), and RNA pulldown assay (g). (h) Detection of miR‐5195‐3p expression in non‐small cell lung cancer (NSCLC) samples and normal samples. (i) Pearson's correlation analysis was used to determine the correlation between miR‐5195‐3p and circERBB2IP expression levels in NSCLC samples. (j) Relative levels of miR‐5195‐3p in NSCLC cell lines. ***p < 0.001.