Table 2.

Drug targets in Trypanosoma and Leishmania parasites

Target	Process	Localization	Organism	Drugs	Reference
Alternative oxidase	Electron transport chain	Mitochondria	T. brucei	Aromatic hydroxamates	Menzies et al. (2018)
Cytochrome b	Electron transport chain	Mitochondria	T. cruzi	GNF7686	Khare et al. (2015)
Lanosterol 14-α-demethylase	Ergosterol biosynthesis	Mitochondria and endoplasmatic reticulum	T. cruzi	Posaconazole Ravuconazole	Morillo et al. (2017); Urbina (2015)
Trypanothione synthase	Thiol metabolism	Cytoplasm	T. brucei T. cruzi Leishmania spp.	Revised in the references	Vazquez et al. (2017); Leroux and Krauth-Siegel (2016); Torrie et al. (2009)
Trypanothione reductase	Thiol metabolism	Cytoplasm	T. brucei T. cruzi Leishmania spp.	Revised in the references	Leroux and Krauth-Siegel (2016); Vazquez et al. (2017); Lu et al. (2013)
Ornithine decarboxilase	Polyamine metabolism	Cytoplasm	T. brucei	DFMO	Burri and Brun (2003)
TcPAT12	Polyamine metabolism	Flagellar pocket	T. cruzi	Isotretinoin ANT4 Triclabendazole Sertaconazole Paroxetine Cisapride	Alberca et al. (2016); Reigada et al. (2018); Reigada et al. (2017); Dietrich et al. (2018)
Enolase	Glycolisis	Cytoplasm and cell surface	T. brucei T. cruzi Leishmania spp.	Phosphonoacetohydroxamate	Avilan et al. (2011)
Piruvate kinase	Glycolisis	Cytoplasm	Leishmania spp.	Furanose sugar amino amides	Nowicki et al. (2008)
Phosphofructokinase	Glycolisis	Glycosome	T. brucei T. cruzi	ML251 Furanose sugar amino amides	Brimacombe et al. (2014); Nowicki et al. (2008)
Hexokinase	Glycolisis	Glycosome	T. brucei	EbSe Revised in the references	Lu et al. (2013); Sharlow et al. (2010a,b)