Table 1.
Trypanocidal effects and selectivity index of the sesquiterpene lactone goyazensolide and benznidazole against T. cruzi Y strain
| Substance | Time | LC50
(MTT) |
EC50
(Amastigotes) |
SI (Amastigotes) |
|---|---|---|---|---|
| GZL | 24 h | 9.56 µm | 0.181 µm | 52.82 |
| BZ | 1.30 µm | 0.268 µm | 4.85 | |
| GZL | 48 h | 18.30 µm | 0.020 µm | 915.00 |
| BZ | 8.20 µm | 0.200 µm | 41.00 |
EC50, compound concentration that reduces the number of parasites in 50%; SI, selectivity index (LC50/EC50 ratio for intracellular parasites) calculated on LC50 after 24 and 48 h of incubation at 37 °C.