Table 2.
Hazard ratios for cardiovascular-specific mortality following quintiles of alcohol use in 14 496 twins
| Quintiles | Cohort (between individuals) | Familial effect (est. between MZ twin pairs) | Individual-specific effects (est. within MZ twin pairs) | |||
|---|---|---|---|---|---|---|
| HR | (95% CI) | HR | (95% CI) | HR | (95% CI) | |
| All levels of consume | ||||||
| 1 | 1.00 | – | 1.00 | – | 1.00 | |
| 2 | 0.73 | (0.61–0.87) | 0.67 | (0.51–0.89) | 1.04 | (0.74–1.47) |
| 3 | 0.79 | (0.66–0.94) | 0.87 | (0.67–1.13) | 0.98 | (0.68–1.40) |
| 4 | 0.60 | (0.49–0.72) | 0.48 | (0.36–0.63) | 1.31 | (0.88–1.96) |
| 5 | 0.61 | (0.48–0.77) | 0.50 | (0.35–0.71) | 1.31 | (0.80–2.16) |
| High consumers v. low | ||||||
| 1 + 2 + 3 | 1.00 | 1.00 | 1.00 | |||
| 4 + 5 | 0.70 | (0.61–0.81) | 0.54 | (0.65–0.83) | 1.33 | (1.02–1.73) |