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. 2023 Jun 13;37(7):1583–1587. doi: 10.1038/s41375-023-01937-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Representative flow cytometry plots (left) and percentages (right) of murine LK and LSK cells following two weeks of LNPs treatment. B Representative flow cytometry plots (left) and percentages (right) of murine HSCs (CD150⁺) and MPPs (CD150⁻) after LNPs treatment. In A and B, lines represent the mean, n = 8 mice per arm. C Left, schematic illustration of LNP treatment for AML PDXs in vivo. Humanized immunodeficient mice were injected with leukemic cells on day 0 and treated with LNPs as shown in the treatment scheme on the right. D Percentage of human CD45⁺ cells in the periphery of transplanted mice. Blood sampling was performed one day before the start of the treatment and after two weeks. Lines represent the mean and statistical significance was calculated based on one-way ANOVA. E Kaplan-Meier survival curves of LNPs-treated PDXs. Statistical significance was calculated using the log-rank test.