Table 5.
Associations Between Brain-Age Delta and Vascular Risk Factors
| Non-IHD |
IHD |
|||
|---|---|---|---|---|
| Beta Value | P Value | Beta Value | P Value | |
| Smokinga | 0.58 | 0.26 | 0.56 | 1.00 |
| Deprivation | 0.05 | 0.33 | 0.05 | 1.00 |
| BMI, kg/m2 | 0.03 | 1.00 | 0.1 | 0.003 |
| Diabetesa | 1.3 | 0.001 | 2.06 | <0.001 |
| Hypertensiona | 0.45 | 1.00 | 0.84 | 1.00 |
| Hypercholesterolemiaa | 0.21 | 1.00 | 0.25 | 1.00 |
| Waist-hip-ratio | 1.72 | 0.81 | 8.02 | <0.001 |
The beta value is interpreted as the difference in the dependent variable (brain-age delta) for changing 1 U in the independent variable (exposure). Specifically, changing 1 U in the exposure leads to increasing (positive beta value) or decreasing (negative beta value) in brain-age delta. For instance, in non-IHD, diabetes is associated with an increased brain-age delta = 1.3 years, whilst in IHD such increase is near 2.1 years. Bold indicates statistically significant after Bonferroni correction (P < 0.05).
a
Indicates categorical variables; the other variables are continuous.