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. 2023 Jun 1;55(6):1065–1075. doi: 10.1038/s12276-023-01004-1

Table 1.

WIRS-containing transmembrane proteins.

Gene name Protein name Sequences and positions of WIRS
PTPRS Receptor-type tyrosine-protein phosphatase S

LATFCV (aa 1526–1531)

LGSFDH (aa 1940–1945)

PTPRD Receptor-type tyrosine-protein phosphatase delta LGSFDH (aa 1904–1909)
PTPRF Receptor-type tyrosine-protein phosphatase F LGSFDH (aa 1899–1904)
EPHA3 Ephrin type-A receptor 3

LDSFLR (aa 707–712)

ITTFRT (aa 910–915)

EPHA5 Ephrin type-A receptor 5 LDTFLK (aa 761–766)
EPHA6 Ephrin type-A receptor 6

LDSFLR (aa 759–764)

IVSFLD (aa 926–931)

FTTFDL (aa 987–992)

EPHA7 Ephrin type-A receptor 7 FTTFCS (aa 922–927)
EPHA8 Ephrin type-A receptor 8

LDTFLR (aa 721–726)

FRTFSS (aa 812–817)

EPHA10 Ephrin type-A receptor 10

FSTFPS (aa 929–934)

FPSFGS (aa 932–937)

EPHB1 Ephrin type-B receptor 1 LDSFLR (aa 705–710)
EPHB2 Ephrin type-B receptor 2

LDSFLR (aa 707–712)

YTSFNT (aa 912–917)

FTSFDV (aa 939–944)

EPHB3 Ephrin type-B receptor 3

LDSFLR (aa 719–724)

YTTFTT (aa 924–929)

FASFDL (aa 951–956)

EPHB4 Ephrin type-B receptor 4

LDSFLR (aa 701–706)

FGSFEL (aa 933–938)

EPHB6 Ephrin type-B receptor 6

LDSFLR (aa 756–761)

LSSFAF (aa 786–791)

LCTFSD (aa 974–979)

BAI2 Adhesion G protein-coupled receptor B2

YPSFLS (aa 1395–1400)

FHTFDR (aa 1492–1497)

WSTFKS (aa 1544–1549)

BAI3 Adhesion G protein-coupled receptor B3 WDTFKN (aa 1470–1475)
NLGN1 Neuroligin-1

LHTFNT (aa 834–839)

FNTFTG (aa 837–842)

NLGN3 Neuroligin-3 YNTFAA (aa 827–832)
NLGN4X Neuroligin-4

LHTFNT (aa 792–797)

FNTFSG (aa 795–800)

LPHN1 Latrophilin-1 ISTFCF (aa 879–884)
UNC5A Netrin receptor UNC5A YGTFNF (aa 444–449)
UNC5C Netrin receptor UNC5C FGSFNS (aa 533–538)
UNC5D Netrin receptor UNC5D

FQTFNF (aa 424–429)

LDSFGT (aa 670–675)

SLITRK6 SLIT and NTRK-like protein 6 FLSFQD (aa 746–751)
DSC2 Desmocollin-2 WHSFTQ(aa 826–831)
DSC3 Desmocollin-3 WHSFTQ(aa 821–826)
PCDHA1 Protocadherin alpha-1 FITFGK (aa 913–918)
PCDHA2 Protocadherin alpha-2 FITFGK (aa 911–916)
PCDHA5 Protocadherin alpha-5 FITFGK (aa 899–904)
PCDHA6 Protocadherin alpha-6 FITFGK (aa 913–918)
PCDHA7 Protocadherin alpha-7 FITFGK (aa 900–905)
PCDHA8 Protocadherin alpha-8 FITFGK (aa 913–918)
PCDHA9 Protocadherin alpha-9 FITFGK (aa 913–918)
PCDHA10 Protocadherin alpha-10 FITFGK (aa 911–916)
PCDHA11 Protocadherin alpha-11 FITFGK (aa 912–917)
PCDHA12 Protocadherin alpha-12 FITFGK (aa 904–909)
PCDHA13 Protocadherin alpha-13 FITFGK (aa 913–918)
PCDHAC1 Protocadherin alpha-C1 FITFGK (aa 926–931)
PCDHAC2 Protocadherin alpha-C2 FITFGK (aa 970–975)
PCDH9 Protocadherin-9 LSTFAP (aa 1158–1163)
PCDH11X Protocadherin-11X LTTFTP (aa 1323–1328)
PCDH11Y Protocadherin-11Y LTTFAP (aa 1316–1321)
PCDH8 Protocadherin-8 MSTFCK (aa 984–989)
PCDH10 Protocadherin-10

MPSFVP (aa 955–960)

FSTFGK (aa 1000–1005)

PCDH17 Protocadherin-17 FCTFGK (aa 998–1003)
PCDH18 Protocadherin-18 FSTFGK (aa 983–988)
PCDH19 Protocadherin-19 FATFGK (aa 1015–1020)
PCDH12 Protocadherin-12 FQTFGK (aa 1087–1092)
FAT2 Protocadherin Fat 2 LVTFGP (aa 4128–4133)
FAT3 Protocadherin Fat 3

MTTFHP (aa 4263–4268)

LSSFQS (aa 4339–4344)

FSTFAV (aa 4482–4487)

CELSR3 Flamingo homolog 1 LASFNS (aa 3250–3255)
TMEM132A Transmembrane protein 132A FVTFAP (aa 965–970)
TMEM132C Transmembrane protein 132C FTTFTT (aa 1056–1061)
TMEM132D Transmembrane protein 132D FTTFTA (aa 1047–1052)
TMEM132E Transmembrane protein 132E FTTFTT (aa 1015–1020)
ROBO1 Roundabout homolog 1 MKTFNS (aa 1050–1055)
ROBO3 Roundabout homolog 3 LQTFHG (aa 1029–1034)
KIRREL1 Kin of IRRE-like protein 1 YSSFKD (aa 572–577)
NEO1 Neogenin LKSFAV (aa 1359–1364)

aa amino acid.

The indicated residue numbers are based on human protein sequences.