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. 2023 Jul 3;9:45. doi: 10.1038/s41522-023-00414-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Venn diagram of unique and shared protein sequences between oral and gut catalogs. b Annotation of 2,854,669 protein sequences according to COG, KO, GO and CAZy databases. c Sequence similarity network of our identified BGCs with known BGCs (similarity >70%,). The nodes in blue represent the known BGCs in the MiBIG database, and the remaining nodes represent identified BGCs in COGR, annotated with the genome name and colored by their species. The width of edges reflects degree of similarity. d Number of annotated ARGs and their distribution. The bottom square is colored according to the importance of drug usage.