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. 2023 Jul 3;9:45. doi: 10.1038/s41522-023-00414-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Genera with relative abundance ranking in top 10 in 4362 metagenomes, colored by phylum. b The top 20 clusters with the highest number of associations to other clusters in COGR in a co-occurrence analysis between the 195 clusters. The clusters are named as “GTDB species_cluster number.” c Co-occurrence heatmap of 29 genera based on the relative abundances in the metagenomes. Red color represents positive relationships while blue represents negative relationships. The stars marked in the boxes represent significance. d Network of 29 genera based on the correlation analysis (r > 0.3). The nodes are colored by phylum. Positive correlations are shown by orange lines and negative correlations by green lines. The width of the lines reflects the strength of the correlation. The phyla color codes are as in Fig. 1.