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. 2023 Jul 3;9:45. doi: 10.1038/s41522-023-00414-3

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Genome-wide comparison of COGR (oral) and CGR2 (gut). The number of matched genomes is shown at the genus level using a Sankey diagram. 367 genomes of COGR match 210 genomes of CGR2. b Differential proteins encoded by COGR and CGR2. The top 5 -log₁₀ (Adjusted p-value) proteins are marked. c KEGG module completeness heatmap of Streptococcus. The modules exhibiting significant differences in COGR or CGR2 are highlighted by stars in green or orange.