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. 2023 Jun 1;55(6):1110–1130. doi: 10.1038/s12276-023-01018-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Alteration of sphingolipids is closely related to human disease. The numbers of reported human studies that analyzed genome-wide association studies, multiomics-based data, Western blot, and PCR comparison of disease tissue to control tissue were counted as visualized (PubMed Gene). The counted numbers are subdivided by color to facilitate understanding of the roles of sphingolipid-related enzymes in human disease.