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. 2023 Jun 1;55(6):1110–1130. doi: 10.1038/s12276-023-01018-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Recent progress in metabolomics and multiomics analysis has enabled the investigation of sphingolipids as a marker of disease. After collection of human blood and disease tissue by biopsy, a series of procedures with mass spectrometry enable the detection of changes in sphingolipids and related molecules compared to levels in healthy volunteers. By analysis of a multiomics database, specific sphingolipids and related enzymes can be detected for human disease. Inhibition of sphingolipid enzymes in a preclinical disease model should enable investigation of the roles of sphingolipids and related enzymes.