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. 2023 Jul 3;13(7):e1321. doi: 10.1002/ctm2.1321

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Transcription factor analysis in intestinal goblet cells. (A) Heat map showing the regulon activity scored using the R package AUCell in epithelial cells. Each row represents a regulon, and each column represents a cell. (B) Expression of transcription factors enriched in goblet cells of the functional (Fu) and defunctioned (De) intestines along the developmental trajectory (*p < .05, **p < .01, ***p < .001, ns = not significant, Wilcoxon rank‐sum test). (C) Immunohistochemistry staining showing the expression of SPDEF in goblet cells of the Fu and De intestines (*p < .05, n = 5, scale bars = 50 μm, paired Wilcoxon rank‐sum test. The values are presented as mean ± SEM of each group).