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. 2023 Jun 20;14:1194861. doi: 10.3389/fphar.2023.1194861

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Copyright © 2023 Chang, Feng, Du, Li, Wang, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The anticancer effects and mechanisms of paeonol. Paeonol can exert anticancer effects through various mechanisms, including 1. Inhibiting the proliferation of various tumor cells; 2. Inhibit cell invasion and migration by inhibiting EMT of tumor cells; 3. Promote intracellular apoptosis through intrinsic and extrinsic pathways; 3. Induce cell cycle arrest, including G1, S, G2, and M phases; 4. Inhibit angiogenesis by targeting VEGF; 5. Promote the formation of autophagosomes and autophagy of cancer cells; 6. Regulating tumor immunity; 7. Reverse multidrug resistance and increase radiosensitivity.