TABLE 2.
No | Study | Male/Female | Mean age (years) | Median time from diagnosis (years) | Lines of prior treatment | Prior ASCT (%) | High-risk cytogenetics (%) | Extramedullary disease (%) | ECOG≥3 level (%) | ISS ≥3 level (%) | mAb exposed (%) | BCMA positivity requirement at enrollment (%) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Lin Y | — | 61 | 5 | 6 | 97 | 45 | 27 | — | — | 90 | — |
2 | Jennifer N. Brudno | — | — | — | 9.5 | 75 | 40 | — | — | — | 44 | — |
3 | Hao S | 13/11 | 60.1 | 3.5 | 4.5 | 42 | 38 | 42 | 33 | 38 | 21 | 91.3 |
4 | Alsina M | — | 62 | — | 6 | 85 | 40 | — | — | — | 72 | — |
5 | Wan-Hong Zhao | 45/29 | 54.5 | 4 | 3 | 24 | 36 | 30 | 16 | 28 | — | — |
6 | Sham Mailankody | — | 53 | 4 | 10 | 88 | 50 | — | — | — | — | — |
7 | Kumar SK | — | 59 | 3.9 | 6 | 57 | 64 | 36 | — | — | — | — |
8 | Sham Mailankody | — | — | — | 6 | — | 82 | — | — | — | 9 | — |
9 | Di Wang | 10/8 | 53.5 | 2.6 | 4 | 33 | 39 | — | — | 0 | 39 | 83 |
10 | Shwetha H. Manjunath | 16/9 | 58 | 4.6 | 7 | 92 | 96 | 28 | — | — | 76 | — |
11 | Damian J. Green | — | 63 | — | 8 | 71 | 71 | — | — | — | — | — |
12 | Jesus G Berdeja MD | 57/40 | 61 | 5.9 | 6 | 90 | 24 | — | 4 | 14 | 84 | >50% (57/62) |
13 | Nikhil C. Munshi | 76/52 | 61 | 6 | 6 | 78 | 78 | 78 | 67 | 76 | — | >50% (85/109) |
14 | XiaoYuan, Zhang | 12/9 | 55 | — | 5 | 38 | 86 | 24 | — | 38 | — | — |
15 | Juan Du | 26/23 | 57 | 2.7 | 4 | 28 | 43 | 22 | 41 | 27 | 9 | 46 |
16 | Xiaoyan Qu | 17/14 | 61 | — | 4 | 23 | 48 | 10 | 0 | 16 | 23 | 49 |
17 | Chen W | — | 54 | — | 6 | 71 | 36 | 14 | — | — | — | — |
18 | Costello CL | 29/14 | 60 | — | 7 | 58 | — | — | — | — | — | — |
19 | Frigault MJ | — | 66 | — | 5 | — | 89 | 67 | — | — | — | — |
20 | Hu Y | — | 62.5 | — | — | — | — | — | — | — | — | — |
21 | Chunrui Li | 17/13 | 55 | 3.7 | 4 | 37 | 80 | 47 | — | 29 | 13 | 93 |
Abbreviations: ASCT, autologous stem cell transplant; ECOG, eastern cooperative oncology group; ISS, international staging system.