TABLE 5.

The additional measures of anti-BCMA CAR-T therapy.

No	Study	mPFS (months)	mOS (months)	mDOR (months)	CAR-BCMA T cell expansion time (days)	CAR-BCMA T cell reached peak value time (days)	CAR-BCMA T cell highest concentration (copies/µg genomic DNA)	Median CAR-BCMA T cell persistence time (days)	Longest CAR-BCMA copies persistence time (days)	Median CRS occurred time (days)	Median CRS resolved time (days)	Increase of endogenous marker
1	Lin Y	8.8	34.2	10.3	—	—	—	—	—	—	—	—
2	Jennifer N. Brudno	7.8	—	—	—	10	—	—	—	—	—	IFN-γ, IL-6, IL-10, GM-CSF, IL-15, IL-8, IL-4, TNF-α
3	Hao S	18.8	—	21.8	4	14	450000	172	341	2.5	6	—
4	Alsina M	—	—	11.9	—	—	—	—	—	3	—	—
5	Wan-Hong Zhao	18	36.1	23.3	2	18	450000	172	341	9	9	IL-6, IL-10, TNF-α, IL-2, IL-8
6	Sham Mailankody	—	—	—	—	—	—	—	—	9	4.5	—
7	Kumar SK	—	—	21.8	3	10	—	—	—	2	4	CRP, IL-6, IFN-γ, IL-8, IL-10
8	Sham Mailankody	—	—	3.5	—	—	90208	—	—	—	—	CRP, IFN-γ, IL-6
9	DiWang	13	—	10.8	—	12	—	307.5	308	2	8	Ferritin, IL-6
10	Shwetha H. Manjunath	—	9.3	—	—	11	27737	—	—	—	—	Ferritin, CRP
11	Damian J. Green	—	—	—	—	—	—	—	—	—	—	—
12	Jesus G Berdeja MD	—	—	—	—	12.7	—	—	—	7	4	—
13	Nikhil C. Munshi	8.8	19.4	10.7	—	11	231278	119	—	1	5	Ferritin, CRP, IL-6, IFN-γ, IL-8, IL-10
14	XiaoYuan, Zhang	7.9	19.4	—	—	14	261000	—	—	2	5	IL-2, IL-6, IL-10, IFN-γ, LDH, CRP, Ferritin, TNF-α
15	Juan Du	10	29	—	—	11	220453	196	—	3	8	IL-6, IFN-γ
16	Xiaoyan Qu	—	—	—	—	14	750061	—	—	7	5	IL-6, IFN-γ
17	Chen W	—	—	—	—	10	45469	—	—	6	7	CRP, IL-6, IFN-γ, IL-8, IL-10
18	Costello CL	—	—	—	5	18	—	—	550	—	—	IL-6
19	Frigault MJ	—	—	—	—	—	—	—	—	—	—	—
20	Hu Y	—	—	—	3	—	—	—	—	—	—	—
21	Chunrui Li	5.3	14.2	4.9	—	—	—	—	—	—	—	Ferritin, IL-6
	Overall	8.77	18.87	10.32	3.50	11.10	225865.50	184.0	341.0	4.80	4.50	CRP, Ferritin, IFN-γ, IL-6, IL-10, GM-CSF, IL-15, IL-2, IL-8, IL-4, TNF-α, LDH