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. 2023 May 31;44(11):4352–4371. doi: 10.1002/hbm.26386

FIGURE 2.

FIGURE 2

Changes in endogenous properties from resting‐state BOLD signals in healthy controls (HC), unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). (a) Illustration of intrinsic ignition computation overview consisting of the identification of intrinsic (endogenous) events occurring in the BOLD and calculation of the network integration (using largest subcomponent of phase lag connectivity) elicited by each of the intrinsic events in a short time window. (b) Comparison of mean intrinsic ignition for the three groups, illustrating the reduced capacity to integrate endogenous spontaneous events in patients with DoC. (c) Representation of the relaxation (autocorrelation) time‐scales of the BOLD signals (τ). A shorter τ implies a faster decay of the signal and a lower memory depth. (d) At the whole‐brain level τ shows significant reductions in UWS and MCS patients compared to HC. Stars reflect the Bonferroni corrected (for three groups) significance levels (*p‐value < 0.05; **p‐value < 0.001; ***p‐value < 0.0001). (e, f) Maps of significant differences in regional distributions of τ between patients and controls. The color bar represents the t‐values of significant between‐group differences (Bonferroni corrected for 214 tests, p‐value = 0.05).