Table 3. Diagnostic performance of LSM for predicting significant and severe inflammation in the internal, external, and prospective validation groups.
| AUC (95%CI) | Cutoff values | Accuracy (%) | Sensitivity/ specificity (%) | PPV/NPV (%) | |
|---|---|---|---|---|---|
| Training group (n=227) | |||||
| A≥2 | 0.803 (0.746–0.853) | 6.3 | 72.25 | 79.63/65.55 | 67.72/78.00 |
| A=3 | 0.765 (0.704–0.819) | 7.5 | 63.00 | 84.62/61.68 | 11.83/98.51 |
| Internal validation group (n=212) | |||||
| A≥2 | 0.796 (0.735–0.848) | 6.3 | 73.58 | 84.62/62.96 | 68.75/80.95 |
| A=3 | 0.793 (0.732–0.845) | 7.5 | 69.81 | 80.00/69.31 | 11.43/98.59 |
| External validation group (n=84) | |||||
| A≥2 | 0.800 (0.669–0.880) | 6.3 | 78.57 | 70.27/85.11 | 72.22/83.33 |
| A=3 | 0.937 (0.862–0.978) | 7.5 | 78.57 | 100/77.22 | 21.74/100 |
| Prospective validation group (n=96) | |||||
| A≥2 | 0.877 (0.790–0.937) | 6.3 | 83.33 | 97.62/72.22 | 73.21/97.50 |
| A=3 | 0.937 (0.862–0.978) | 7.5 | 78.13 | 100/76.40 | 25.00/100 |
AUC, area under the receiver operating characteristic curve; LSM, liver stiffness measurement; NPV, negative predictive value; PPV, positive predictive value.