Table 4. Univariate and multivariate analysis of the relationship between noninvasive indexes and significant liver inflammation in cohort I.
| Variables | Univariate analyses |
Multivariate analyses |
||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| Age (yr) | 0.99 (0.97–1.01) | 0.648 | ||
| Male (%) | 1.26 (0.85–1.89) | 0.255 | ||
| BMI (kg/m2) | 1.17 (1.05–1.31) | 0.008 | 1.15 (1.00–1.32) | 0.056 |
| TBIL (µmoL/L) | 0.99 (0.96–1.01) | 0.376 | ||
| ALB (g/L) | 1.00 (0.95–1.05) | 0.918 | ||
| GLOB (g/L) | 1.16 (1.10–1.22) | < 0.001 | 1.14 (1.05–1.24) | 0.002 |
| ALT (IU/L) | 1.03 (1.00–1.05) | 0.036 | 0.99 (0.95–1.04) | 0.705 |
| AST (IU/L) | 1.06 (1.03–1.10) | < 0.001 | 1.03 (0.98–1.08) | 0.236 |
| GGT (IU/L) | 1.00 (0.99–1.01) | 0.708 | ||
| ALP (IU/L) | 1.01 (1.00–1.02) | 0.060 | ||
| PLT (109/L) | 1.00 (1.00–1.01) | 0.978 | ||
| HBsAg (logIU/mL) | 1.11 (0.94–1.31) | 0.210 | ||
| HBeAg positive (%) | 1.16 (0.79–1.71) | 0.456 | ||
| HBV DNA (logIU/mL) | 1.01 (0.93–1.10) | 0.818 | ||
| PT (s) | 0.99 (0.81–1.21) | 0.941 | ||
| AFP (ng/mL) | 1.00 (0.98–1.01) | 0.517 | ||
| LSM (kPa) | 1.66 (1.47–1.88) | < 0.001 | 1.62 (1.36–1.92) | < 0.001 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; ALB, albumin; AFP, alpha fetoprotein; BMI, body mass index (kg/m2); GGT, gamma-glutamyl transpeptidase; GLOB, globulin; HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B envelope antigen; LSM, liver stiffness measurements; PLT, platelet count; PT, prothrombin time; TBIL, total bilirubin.