Skip to main content
. 2023 Mar 1;11(4):958–966. doi: 10.14218/JCTH.2022.00408

Fig. 2. Bile acid-microbiota interactions are impaired in PBC patients.

Fig. 2

(A) Gut dysbiosis and decreased BSH deconjugation result in impaired microbial bile acid metabolism, particularly an increase in the ratio of conjugated/unconjugated bile acids and a decrease in the ratio of secondary/primary bile acids. (B) Serum FGF19 is elevated in patients with PBC, further inhibiting CYP7A1 transcription and bile acid synthesis. BAs, bile acids; BSH, bile salt hydrolase; CYP7A1, cholesterol 7-alpha-hydroxylase; FGF19, fibroblast growth factor 19; FXR, farnesoid X receptor.