TABLE 3.
Anatomical regions with significantly altered structural covariance of the posterior hippocampus in the migraine group, SCD group, and healthy controls.
| MNI coordinates | Cluster size | Maximum t-value |
Anatomical region | Integrity of structural covariance | ||
| x, y, z | HC | SCD | MIG | |||
| HC > SCD | ||||||
| 16, −33, 51 | 642 | 3.93 | Rt. postcentral gyrus | 0.352 | 0.265 | 0.291 |
| −50, 2, 18 | 339 | 3.84 | Lt. precentral gyrus | 0.391* | 0.380* | 0.268 |
| 54, −54, −39 | 278 | 3.53 | Rt. cerebellum crus I | 0.288 | -0.332 | 0.314* |
| HC < SCD | ||||||
| 23, −98, 15 | 419 | 4.50 | Rt. occipital pole | -0.585** | 0.343 | 0.224 |
| −35, −92, 15 | 1289 | 4.12 | Lt. occipital pole | -0.34 | 0.261 | 0.229 |
| 2, 29, 18 | 436 | 3.60 | Rt. anterior cingulate gyrus | -0.023 | 0.436* | 0.134 |
| HC > MIG | ||||||
| 14, 11, 69 | 563 | 3.89 | Rt. superior frontal gyrus | 0.332 | 0.295 | -0.003 |
| −50, 3, 15 | 342 | 3.73 | Lt. precentral gyrus | 0.397* | 0.419* | 0.209 |
| −26, −50, −60 | 602 | 3.20 | Lt. cerebellum VIIIa | 0.376* | 0.115 | 0.135 |
| HC < MIG | ||||||
| 35, 27, −35 | 333 | 4.18 | Rt. temporal pole | -0.087 | 0.358* | 0.299 |
| 20, −43, 1 | 614 | 3.82 | Rt. posterior cingulate gyrus | -0.021 | 0.408* | 0.498** |
| −2, 22, 25 | 409 | 3.34 | Lt. anterior cingulate gyrus | -0.272 | 0.309 | 0.155 |
Peak of group differences in the integrity of structural covariance of the posterior hippocampus with a threshold of FWE-corrected p-value < 0.05.
*p < 0.05; **p < 0.001.
HC, healthy controls; Lt, left; MIG, migraine; MNI, Montreal Neurological Institute; Rt, right; SCD, subjective cognitive decline.