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. 2023 Mar 3;119(7):1568–1582. doi: 10.1093/cvr/cvad037

Figure 7.

Figure 7

Phospholamban (PLN) pentamerization protects from pressure-overload induced heart failure. Seven weeks after transverse aortic constriction (TAC), TgPLN show longer survival, less interstitial collagen deposition, less left ventricular (LV) dilation, and better cardiac haemodynamics than TgAFA-PLN and PLN-KO. (A) Kaplan-Meier survival curves after TAC; log-rank test for TgPLN vs. TgAFA-PLN (P = 0.0389) and PLN-KO (P = 0.042). (B) Heart weight (HW) to tibia length (TL) ratios. (C, D) Representative histological pictures (scale bars 100 μm) and quantitative analysis of red staining in serial LV sections after Sirius Red staining. (E) Speed of LV pressure decay (dp/dtmin) and pressure rise (dp/dtmax), maximum pressure (LVPmax) and heart rate, as determined by LV catheterization of anaesthetized mice. Measurements were obtained before and after intravenous infusion of 1.5 μg/min dobutamine (Dob). Groups were compared by two-way ANOVA followed by Tukey’s multiple comparisons test.