Table 1.
Echocardiography 7 weeks after TAC
| PLN-KO | TgAFA-PLN | P vs. PLN-KO | TgPLN | P vs. PLN-KO | P vs. TgAFA-PLN | |
|---|---|---|---|---|---|---|
| N | 12 | 17 | 12 | |||
| Pressure gradient (mm Hg) | 68 ± 7 | 73 ± 5 | 0.94 | 70 ± 7 | 0.96 | 0.81 |
| LVAW;d (mm) | 1.25 ± 0.02 | 1.32 ± 0.02 | 0.29 | 1.24 ± 0.05 | 0.99 | 0.26 |
| LVPW;d (mm) | 1.24 ± 0.03 | 1.29 ± 0.02 | 0.61 | 1.24 ± 0.05 | 0.99 | 0.54 |
| LVID;d (mm) | 3.60 ± 0.11 | 3.52 ± 0.11 | 0.83 | 3.26 ± 0.10 | 0.10 | 0.21 |
| LVID;s (mm) | 2.64 ± 0.12 | 2.25 ± 0.13 | 0.08 | 1.85 ± 0.12 | 0.0006 | 0.08 |
| FS (%) | 27 ± 1 | 37 ± 2 | 0.005 | 44 ± 2 | <0.0001 | 0.07 |
| LV volume;d (μL) | 55 ± 4 | 53 ± 4 | 0.85 | 44 ± 3 | 0.10 | 0.20 |
| LV volume;s (μL) | 27 ± 3 | 19 ± 2 | 0.07 | 11 ± 2 | 0.0005 | 0.08 |
| LV mass (mg) | 190 ± 8 | 198 ± 9 | 0.80 | 165 ± 11 | 0.24 | 0.05 |
| heart rate (bpm) | 589 ± 17 | 557 ± 13 | 0.34 | 540 ± 20 | 0.13 | 0.74 |
N, number of mice; transstenotic pressure gradient; LVAW, left ventricular anterior wall thickness; d, diastolic; LVPW, left ventricular posterior wall thickness; LVID, left ventricular internal dimension; s, systolic; FS, fractional shortening; bpm, beats per min; mean ± SEM; P-values were determined by one-way-ANOVA, values in bold indicate statistically significant results.