Table 3.
Toxicity.
| IORT + WBI | SIB | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Toxicity grade n (%) | |||||||||
| 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | p-value | |
| Acute toxicity post WBI | |||||||||
| Dermatitis | 4 (6.6) | 23 (38.3) | 26 (43.3) | 6 (10) | 1 (1.7) | 3 (5.1) | 21 (35) | 7 (11.6) | 0.309 b |
| Seroma/hematoma breast | 53 (88.3) | 7 (11.7) | 58 (96.7) | 2 (3.3) | 0.078 b | ||||
| Seroma/hematoma axilla | 59 (98.3) | 1 (1.7) | 60 (100) | 0.315 b | |||||
| Wound infection | 59 (98.3) | 1 (1.7) | 60 (100) | 0.315 b | |||||
| Wound dehiscence | 59 (98.3) | 1 (1,7) | 60(100) | 0.315 b | |||||
| Fatigue | 47 (78.3) | 13 (21.7) | 55 (91.7) | 4 (6.7) | 1 (1.7) | 0.041 b | |||
| Pain | 47 (78.3) | 13 (21.7) | 49 (81.6) | 10 (16.7) | 1 (1.7) | 0.488 b | |||
| Lymphodema | 53 (88.3) | 7 (11.7) | 59 (98.3) | 1 (1.7) | 0.026 b | ||||
| Late toxicity post WBI | |||||||||
| Dermatitis | 57 (95) | 3 (5) | 59 (98.3) | 1 (1.7) | 0.133 b | ||||
| Seroma/hematoma breast | 54 (90) | 6 (10) | 58 (96.7) | 2 (3.3) | 0.143 b | ||||
| Seroma/hematoma axilla | 60 (100) | 60 (100) | |||||||
| Wound infection | 60 (100) | 60 (100) | |||||||
| Fatigue | 54 (90) | 6 (10) | 50 (83.3) | 10 (16.7) | 0.283 b | ||||
| Pain | 51 (85) | 9 (15) | 51 (85) | 9 (15) | 1 b | ||||
| Lymphodema | 53 (88.3) | 7 (11.7) | 51 (85) | 9 (15) | 0.591 b | ||||
IORT, intraoperative radiotherapy; WBI, whole breast irradiation.
b
Chi-squared test.
Acute and chronic radiotherapy-related toxicities after IORT + WBI and SIB + WBI according to the Common Terminology Criteria for Adverse vents (CTCAE v5.0).