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. 2023 Jul 3;220(10):e20230461. doi: 10.1084/jem.20230461

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© 2023 Michelson et al.

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Figure 5. — Hnf4 acts on enhancers and CTCF, but not promoters or heterochromatin. (A) Genome browser tracks for merged CUT&RUN signal (n = 2 replicates for each) for the indicated factors in mTECs derived from mice of the indicated genotypes at the H2-A/E loci. Signal is in CPM. (B) Profile plots of aggregated signal for the indicated factors centered on entero-hepato–specific OCRs plus 2.5 kilobases (kb) upstream and downstream. Signal is in CPM, dark lines indicate mean signal, and shading around lines indicates SEM. P-values were calculated by two-sided, paired Student’s t test of CUT&RUN signal at the central 100 bp of entero-hepato OCRs in Hnf4^Ctrl vs. Hnf4^ΔTEC mice, with Bonferroni correction. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001. (C) Genome browser tracks for the indicated factors in mTECs at the indicated loci. Signal is in CPM.