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. 2023 Jul 3;220(10):e20230461. doi: 10.1084/jem.20230461

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© 2023 Michelson et al.

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Figure S2. — Thymic compartments in Hnf4^ΔTEC mice. (A) Body weights of Hnf4^Ctrl (n = 8) versus Hnf4^ΔTEC (n = 4) mice. (B) Thymus weights of Hnf4^Ctrl (n = 8) versus Hnf4^ΔTEC (n = 4) mice. (C) Thymic epithelial cell (EpCAM⁺ CD45⁻) numbers in Hnf4^Ctrl (n = 3) versus Hnf4^ΔTEC (n = 6) mice. (D) Fractional abundance of the indicated TEC compartments in Hnf4^Ctrl (n = 6) versus Hnf4^ΔTEC (n = 3) mice. (E) Hematopoietic cell (CD45⁺) numbers in Hnf4^Ctrl (n = 8) versus Hnf4^ΔTEC (n = 5) mice. (F) Fractional abundance of the indicated thymocyte compartments in Hnf4^Ctrl (n = 8) versus Hnf4^ΔTEC (n = 4) mice. For A, B, and D–F, data were pooled from two independent experiments. For C, data are representative of at least two independent experiments. (G) Expression of Aire in MHCII-high mTECs from Hnf4^Ctrl and Hnf4^ΔTEC mice, assayed by bulk RNA-seq. (H) Expression of Hnf4a and Hnf4g in MHCII-high mTECs from Aire^+/+ and Aire^−/−, assayed by bulk RNA-seq reanalyzed from Bansal et al. (2021). For all plots, each dot represents one mouse and bars represent mean ± SEM.