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. 1989 Aug;52(8):1006–1009. doi: 10.1136/jnnp.52.8.1006

Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology.

E M Jones 1, A Dawson 1
PMCID: PMC1031845  PMID: 2795057

Abstract

The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics. The aetiology and pathophysiology of the syndrome are reviewed, and a fatal case is presented where both brain and muscle pathology are described. Striking myopathic changes in this case, accompanied by only minimal and non-specific brain abnormalities, support a peripheral rather than central mechanism for the hyperthermia.

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Selected References

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