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. 2023 Apr 24;299(6):104748. doi: 10.1016/j.jbc.2023.104748

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

A proposed model for Fur regulation in response to elevation of intracellular free iron content in E. coli cells.A, when intracellular free iron content is depleted, Fur does not bind any [2Fe-2S] clusters (Apo-Fur) and is inactive to bind the Fur-box. B, when intracellular free iron content is elevated, Fur assembles a [2Fe-2S] cluster from intracellular free Fe(II) and sulfide that is provided by L-cysteine and cysteine desulfurase (IscS). Fur becomes active to bind the Fur-box upon binding of a [2Fe-2S] cluster. A structural Zn(II) binding site is shown in both Apo-Fur and the [2Fe-2S] cluster-bound Fur. Fur, ferric uptake regulator.