. 2023 May 11;299(6):104816. doi: 10.1016/j.jbc.2023.104816

Table 1.

Potency of somatostatin, octreotide, lanreotide, pasireotide and CRN02481 at human and mouse somatostatin receptors

Receptor	SS14				Octreotide				Lanreotide				Pasireotide				CRN02481
	Human		Mouse		Human		Mouse		Human		Mouse		Human		Mouse		Human		Mouse
	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)	pEC₅₀ ± SEM	EC₅₀ (nM)
SST1	9.0 ± 0.1	1.0	ND	ND	<5.0	>10,000	ND	ND	<5.0	>10,000	ND	ND	6.7 ± 0.2	180	ND	ND	<6.0	>1000	ND	ND
SST2	9.9 ± 0.1	0.13	10 ± 0.5	0.03	10 ± 0.1	0.06	11 ± 0.0	0.02	10 ± 0.0	0.1	10.6	0.03	9.2 ± 0.1	0.59	9.1 ± 0.1	0.88	6.4 ± 0.0	440	6.5 ± 0.1	320
SST3	9.8 ± 0.0	0.16	9.8 ± 0.1	0.15	8.3 ± 0.1	5.2	ND	ND	6.7 ± 0.1	200	ND	ND	9.1 ± 0.1	0.78	ND	ND	7.4 ± 0.1	39	8.0 ± 0.1	10
SST4	9.7 ± 0.0	0.20	ND	ND	6.4 ± 0.1	450	ND	ND	6.1 ± 0.1	820	ND	ND	<5.1	>8100	ND	ND	8.2 ± 0.1	5.7	ND	ND
SST5	10 ± 0.1	0.06	10 ± 0.1	0.07	8.6 ± 0.1	2.7	12 ± 0.1	0.002	7.8 ± 0.1	16	ND	ND	10.1 ± 0.1	0.081	10.5	0.032	9.4 ± 0.1	0.37	10 ± 0.1	0.04

ND: Not determined. pEC₅₀ and SEM given with two significant figures.