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. 2023 Jul 4;13(29):19846–19855. doi: 10.1039/d3ra03183g

Screening of solvents for the synthesis of 2,4,5-triarylimidazole using CuB4O7.

Entry Catalysta Solventb Yieldc (%)
1 CuB4O7 Methanol 92
2 Ethanol 88
3 DMF 86
4 DMSO 82
5 Water 32
6 Silica gel 91
7 Neat 98
a

The reaction was performed with benzil 1 (1 mmol), 2-nitrobenzaldehyde 2 (1 mmol), and NH4OAc 3 in the presence of different copper(ii) salts in different solvent/neat conditions at 80 °C for 2 h except for neat condition.

b

Under neat condition, the reaction completed in 10 min.

c

Isolated yield.