Screening of solvents for the synthesis of 2,4,5-triarylimidazole using CuB4O7.
| Entry | Catalysta | Solventb | Yieldc (%) |
|---|---|---|---|
| 1 | CuB4O7 | Methanol | 92 |
| 2 | Ethanol | 88 | |
| 3 | DMF | 86 | |
| 4 | DMSO | 82 | |
| 5 | Water | 32 | |
| 6 | Silica gel | 91 | |
| 7 | Neat | 98 |
The reaction was performed with benzil 1 (1 mmol), 2-nitrobenzaldehyde 2 (1 mmol), and NH4OAc 3 in the presence of different copper(ii) salts in different solvent/neat conditions at 80 °C for 2 h except for neat condition.
Under neat condition, the reaction completed in 10 min.
Isolated yield.