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. 2023 Jul 4;14:84. doi: 10.1186/s40104-023-00886-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Chronic cold exposure induces colonic barrier injury and mitochondrial dysfunction in Yorkshire pigs. A Pathological sections and ultrastructure of the colon of Yorkshire pigs. The arrows show the infiltration of inflammatory cells. B The mRNA expression of inflammatory cytokines and antimicrobial peptides in colon mucosa of Yorkshire pigs. n = 6. C The mRNA expression of tight junction proteins, inflammatory pathways, apoptosis and mitophagy related genes in colon mucosa of Yorkshire pigs. n = 6. D Protein expression in the colon mucosa of Yorkshire pigs. n = 4. E Correlation coefficients between mucus layer, inflammatory response, and epithelial barrier. Correlation coefficients > 0.5 or ≤ 0.5. Orange and blue colors denote positive and negative correlations, respectively. Color intensity is proportional to Spearman’s rank correlation values. n = 6. ^*P < 0.05. Other factors without significant changes are shown in Fig. S4