Table 2.
Current night shift work and NAFLD odds in the UK Biobank
| Variables | Never/rarely night shifts | Some night shifts |
Usual/permanent night shifts |
Ptrend | Mediation effect (%) (95% CI) |
|---|---|---|---|---|---|
| Case/Sample | 2243/256605 | 161/13857 | 151/10818 | ||
| Incidence rate (/100,000 person years) | 72.85 | 97.31 | 116.61 | ||
| Model 1 | 1.00 (ref) | 1.35 (1.15–1.58) | 1.61 (1.36–1.90) | < 0.001 | |
| Model 2 | 1.00 (ref) | 1.17 (1.00–1.38) | 1.32 (1.12–1.56) | < 0.001 | |
| Model 3 | 1.00 (ref) | 1.12 (0.96–1.31) | 1.27 (1.08–1.48) | 0.003 | |
| Mediation model | 1.00 (ref) | 1.04 (0.89–1.22) | 1.19 (1.01–1.39) | 0.050 |
31.7 (14.3–56.4) P < 0.001 |
Cox proportional hazards regression models for NAFLD were performed
Model 1 was adjusted for age, sex, and ethnicity (white or others)
Model 2 was model 1 plus further adjustment for Townsend deprivation index, education level (university/college degree or others), household income (less than £18,000, £18,000 to £30,999, £31,000 to £51,999, £52,000 to £100,000, greater than £100,000, or do not know/prefer not to answer), self-reported smoking status (never, former or current smoker), self-reported frequency of alcohol intake (daily/almost daily, 1–4 times a week, 1–3 times a month, or special occasions only/never), and physical activity level (< 600, 600–3000, > 3000 MET minutes per week, or missing)
Model 3 was model 2 plus further adjustment for diabetes, hypertension, and PRS for NAFLD
The mediation model was adjusted for BMI separately in addition to model 3, and the mediation effect was calculated