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. 2023 Jul 3;13:124. doi: 10.1186/s13578-023-01060-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The expression pattern of 42 serine protease in human tissues. (A and B) The tissue-specific expression analysis of 24 PRSS genes and 18 TMPRSS genes. The expression data (RPKM value) of 42 serine proteases in various human tissues was available from the HPA project using the NCBI website. The dot plot is generated using relative expression value of each serine protease. In short, the relative expression value of each gene was obtained by making the sum of the RPKM value of each gene in all tissues be 1. (C-F) Single-cell analysis revealed the distinct cell types of the tissue-specific serine proteases, including PRSS27, PRSS57, TMPRSS6 and TMPRSS15. All single-cell plots here were screenshots from the HPA database