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The working model of the CT antigen PRSS56 in GC and CRC. Briefly, PRSS56 was a novel CT antigen specifically expressed in normal testis, and its expression was frequently reactivated in diverse tumors, especially gastrointestinal cancer. In GC and CRC, PRSS56 overexpression was due to its reduced methylation level of PRSS56 promoter at CpG site cg10242318. In turn, PRSS56 overexpression promoted GC and CRC progression by activating PI3K/AKT axis
