Table 2.
Pregnancy complications (preeclampsia, preterm birth, and/or small for gestational age) in first or last pregnancy by the mother’s total number of births and the relation to maternal CVD death. First births included up to 2013, mothers followed through 2020 (n = 1,011,767)
| Reproduction | Total N | CVD deaths a: N (row %) | Crude HR (95% CI) |
Adjusted HR (95%CI) b | Adjusted HR (95%CI) c |
|---|---|---|---|---|---|
| One child only | |||||
| No complications | 128 586 (14.0) | 815 (0.63) | 1.54 (1.42–1.69) | 1.47 (1.34–1.61) | 1.47 (1.34–1.61) |
| Complication | 41 854 (4.6) | 510 (1.22) | 2.82 (2.54–3.12) | 2.50 (2.25–2.78) | 2.48 (2.23–2.76) |
| Two births | |||||
| No complications | 359 911 (39.2) | 1275 (0.35) | Reference | Reference | Reference |
| Complication only first | 69 470 (7.6) | 384 (0.55) | 1.48 (1.32–1.66) | 1.41 (1.26–1.58) | 1.40 (1.24–1.57) |
| Complication only last | 35 221 (3.8) | 267 (0.76) | 1.94 (1.70–2.21) | 1.82 (1.59–2.08) | 1.76 (1.53–2.01) |
| Three births | |||||
| No complications | 178 612 (19.5) | 518 (0.29) | 1.03 (0.93–1.34) | 1.04 (0.94–1.15) | 1.04 (0.93–1.15) |
| Complication only first | 32 744 (3.6) | 157 (0.48) | 1.54 (1.31–1.82) | 1.49 (1.27–1.76) | 1.49 (1.25–1.77) |
| Complication only last | 14 795 (1.6) | 103 (0.70) | 2.24 (1.83–2.74) | 2.06 (1.68–2.52) | 2.05 (1.66–2.53) |
| Four births | |||||
| No complications | 35 035 (3.8) | 114 (0.33) | 1.29 (1.07–1.57) | 1.25 (1.03–1.52) | 1.26 (1.04–1.54) |
| Complication only first | 6827 (0.7) | 34 (0.50) | 1.85 (1.31–2.60) | 1.74 (1.24–2.45) | 1.74 (1.18–2.57) |
| Complication only last | 3149 (0.3) | 26 (0.83) | 3.19 (2.16–4.70) | 2.85 (1.93–4.20) | 3.18 (2.16–4.70) |
| Five-eight births | |||||
| No complications | 8000 (0.9) | 38 (0.47) | 2.28 (1.65–3.15) | 2.15 (1.56–2.97) | 2.17 (1.56–3.03) |
| Complication only first | 1595 (0.2) | 12 (0.75) | 3.27 (1.85–5.77) | 2.88 (1.63–5.08) | 3.31 (1.83–5.99) |
| Complication only last | 1795 (0.2) | 20 (1.11) | 5.19 (3.34–8.08) | 4.49 (2.88–6.99) | 4.55 (2.68–7.71) |
| Total number of mothers d | 917 594 | 4273 | 917 594 | 908 405 | 896 463 |
Note: a death up to 69 years, b adjusted for maternal education and maternal age at first birth, c adjusted for maternal education and maternal age at first birth excluding perinatal death, d missing values in the complication variables led to some reduction in the sample size