Table 1.
Reactive oxygen and calcium related genes behavior comparison between NNAT overexpression ER + breast cancer cells lines (T47D and ZR75) vs. poor prognosis tumorigenesis in clinical reports. Opposite expression patterns marked in bold
| NNAT overexpression significantly regulated genes | During NNAT overexpression | Expression pattern under tumorigenesis and/or poor prognosis |
|---|---|---|
| PML | ↑ | ↓ [61] breast cancer |
| MELK | ↓ | ↑ [62] breast cancer |
| NOL3 | ↑ | ↓ [63] myeloid malignancies |
| APOE | ↑ | ↑ [64] melanoma and glioblastoma exhibited accelerated tumor growth in ApoE-deficient mice |
| SOD3 | ↑ | ↓ [65] breast cancer, head and neck cancer, lung cancer, and sarcoma |
| PINK1 | ↑ | ↓ [66] breast, colorectal, esophageal, head and neck, liver and ovarian cancers, leukemia and melanoma |
| NDUFS8 | ↑ | ↓ [67] Renal cell carcinoma |
| NDUFS1 | ↓ | ↑ [68] breast cancer (The Human Protein Atlas data) |
| NDUFA3 | ↑ | ↓↑ [68] breast cancer (The Human Protein Atlas data) |
| CYP1B1 | ↓ |
↑ [69] breast, brain, colon, ovarian, and prostate cancers |
| GPX3 | ↓↑ | ↓ [70] breast cancer |
| PDK1 | ↓ | ↑ [71] breast cancer |
| DHRS2 | ↓ | ↓ [72] breast cancer |
| ANXA1 | ↓ | ↑ [73] breast cancer |
| APOD | ↓ | ↑ [74] breast cancer |
| NCF2 | ↓ | ↑ [75] kidney Renal Clear Cell Carcinoma |
| RAC2 | ↑ | ↓ [68] breast cancer (The Human Protein Atlas data) |
| BCL2 | ↓ | ↓ [76] breast cancer |
| BCL2L2-PABPN1 | ↑ | ↑ [77, 78] glioblastoma |
| BBC3 | ↑ | ↓ [79] head and neck cancer |