Fig. 3.

Choroid plexus NKCC1 transport activity is unaltered in SHRs. a Loss of ⁸⁶Rb⁺ from the choroid plexus as a function of time in WKY rats (n = 5) and SHRs (n = 5) in presence or absence of 20 µM bumetanide (bum). The y-axis is the natural logarithm of the choroid plexus ⁸⁶Rb⁺ amount left at time T (A_T) divided by the initial amount at time 0 (A₀). b Efflux rate constant for ⁸⁶Rb⁺ in WKY rats (n = 5) and SHRs (n = 5) in presence or absence of 20 µM bumetanide (bum). c NKCC1-mediated ⁸⁶Rb⁺ efflux rate constant (bumetanide-sensitive fractions) in WKY rats (n = 5) and SHRs (n = 5). Error bars represent standard deviation and statistical significance was tested with one-way ANOVA followed by Sidak’s multiple comparisons test or an unpaired-two tailed t-test. ***P < 0.001, NS = not significant