Table 3.

Fixed Effect Test Results for the Secondary Analysis of Potential Covariates, Predictors of Neurodevelopmental Compromise and Treatment Related Effects on the Two Signatures, Derived from the MMRM Models

	Subtype 1		Subtype 2
	F	P *	F	P *
CTQ Subscale scores
Emotional abuse	1.79	0.1869	0.07	0.7864
Physical abuse	0.89	0.3497	0.12	0.7266
Sexual abuse	1.75	0.1918	1.36	0.2488
Emotional neglect	0.70	0.4053	0.02	0.8814
Physical neglect	0.13	0.7181	0.23	0.6353
PAS Subscale scores
Childhood	0.43	0.5158	0.04	0.8364
Early adolescence	2.82	0.0973	0.99	0.3219
Late adolescence	0.12	0.7289	3.87	0.0530
PANSS domain scores
Positive	0.57	0.4536	20.22	<0.0001
Negative	0.17	0.6794	0.26	0.6147
Disorganized	1.41	0.2397	0.33	0.5660
NES Subscale scores
Sensory Integration	5.19	0.0256	0.54	0.4643
Motor Coordination	1.81	0.1824	0.32	0.5757
Motor sequencing	0.71	0.4018	0.51	0.4770
MCCB cognitive domains
Speed of processing	0.36	0.5497	0.41	0.5274
Attention and vigilance	0.62	0.4342	0.00	0.9988
Working memory	6.13	0.0175	0.02	0.9026
Verbal learning	0.00	0.9831	0.52	0.4739
Visual learning	4.36	0.0430	0.05	0.8161
Reasoning and problem solving	4.64	0.0371	0.46	0.5034
Social cognition	0.36	0.5553	0.47	0.4959
Fasting blood glucose and lipids
Glucose	1.06	0.3061	2.21	0.1420
HDL-cholesterol	0.17	0.6846	0.38	0.5393
LDL-cholesterol	0.97	0.3280	0.04	0.8358
Triglycerides	0.08	0.7759	5.28	0.0245
Cholesterol	0.12	0.7322	0.86	0.3565

Note: CTQ, Childhood Trauma Questionnaire; PAS, Premorbid Adjustment Scale; PANSS, Positive and Negative Syndrome Scale; NES, Neurological Evaluation Scale; MCCB, MATRICS Cognitive Consensus Battery; HDL, high-density lipoprotein; LDL, low-density lipoprotein.

^*P values uncorrected for multiple comparisons.