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. 2023 Jun 26;120(27):e2301067120. doi: 10.1073/pnas.2301067120

Fig. 2.

Fig. 2.

Synchrotron SAXS data of LNP–siRNA and LNP–mRNA complexes under dilute conditions show bicontinuous cubic (QII), 2D reversed hexagonal (HII) and lamellar phases (L). (A) QII, HII LNP–RNA complexes were formed with a lipid composition of GMO/DOTAP/DOPE-PEG at molar ratio 85/14/1 and mixed with siRNA or mRNA at ρ = 3. (B) HII, L LNP–RNA complexes were formed with a lipid composition of GMO/DOPC/DOTAP/DOPE-PEG at molar ratio 50/35/14/1 and mixed with siRNA at ρ = 3. (C) L LNP–RNA complexes were formed with a lipid composition of DOPC/DOTAP/DOPE-PEG at molar ratio 85/14/1 and mixed with siRNA or mRNA at ρ = 3.