TABLE 3.

scRNA-seq for identifying autoimmune disease-related TCR.

Disease	Finding	References
T1D	Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)206–214-reactive CD8+ T (self-reactive T cells) in T1D may inherently have a restricted TCR library as well as a substantial TCR motif overlap	Kasmani et al. (2022)
T1D	It has identified a class of autoreactive TCRs from human IAR (islet antigen reactive) CD4+ T cells in patients with T1D that share the feature of germline alpha chains	Linsley et al. (2021)
AIH	Identified the central memory CD45RA−CD27+PD-1+CXCR5−CCR6− CD4+ T cell population as the significant self-reactive CD4+ T cell pool in AIH	Renand et al. (2020)
pSjD	T cell receptor alpha and beta chain variable genes of TRAV13-2 and TRBV7-9 were significantly expanded in patients with pSjD	Hong et al. (2020)
pSjD	The degree of TCR clonal expansion did not differ significantly between the pSjD patients and healthy individuals. Still, the frequencies of T cells with dual TCR β-chain expression were reduced considerably in pSjD patients	Hou et al. (2022)
SLE	Found CD8+ kidney-infiltrating T cells (KIT) first existed in a transitional state, then clonally expanded and evolved to depletion in the kidney	Smita et al. (2022)

T1D, Type 1 diabetes; AIH, Autoimmune hepatitis; pSjD, Primary Sjögren’s disease; SLE, Systemic lupus erythematosus.