TABLE 4.

TCR (-pMHC) modeling platforms and capabilities.

Platform	TCRα	TCRβ	CDR3	MHC present	Output	Limitations
TCRModel	Yes	Yes	Yes	Yes	Unbound TCR, as well as TCR-pMHC complex modeling	NA
NetTCR	No	No	Yes	HLA-A*02:01 Only	List of predicted epitope binding	Only select from three peptide sequences
SCALOP-TCR	Yes	Yes	Yes	No	Predicts the structure of five CDRs (B1-2 and A1-3)	Does not include side chains
TCRBuilder	Yes	Yes	Yes	No	Multiple predicted conformations and an ensemble conformation would be returned	NA
TCRex	No	Yes	Yes	No	List of reactive epitopes	Only select from 93 viral and 5 cancer epitopes
TCRpMHCmodels	Yes	Yes	Yes	Class I only	TCR-pMHC complex modeling	Class I Only